Helen Wills Moody won 31 Grand Slam titles in the 1920s and 1930s. She helped to popularize the overhand serve for women during the 1940s.[17] Alice Marble is another important influential American tennis player. In 1939, she was a triple champion at Wimbledon. Her style of play was characterized as masculine because of her aggressive pursuit of the ball during serves and volleys. Like Helen Wills Moody, others would go on to copy her style of play.[17] Maureen Connolly won the four Grand Slam singles tournaments in 1953.[18]

Althea Gibson was the first African American woman to win a Grand Slam tournament.[19] She claimed the singles title at the French Championships in 1956, and at Wimbledon and the US Nationals in 1957 and 1958.

In the Open Era, the United States has produced some of the most influential and successful players including Billie Jean King, Chris Evert, Martina Navratilova (defected from Czechoslovakia), Monica Seles (defected from Serbia and Montenegro), Venus Williams, and Serena Williams. The arrival of the Williams sisters is credited as the ushering in of a new era of power and athleticism on the women's tour and 23 time Grand Slam champion Serena Williams is considered by many to be the greatest women's player of all time.